UM-UC-1 (Human bladder transitional cell carcinoma) cell line

A human bladder cancer model widely used to explore tumourigenesis, biomarker discovery, and preclinical drug development. Save 30% on this cell line this summer. Use code SUM26CELL at checkout.

Contributors

Inventor Institute
H. Grossman ; Anita Sabichi University of Michigan
SKU: 160436
Product description: UM-UC-1 was isolated from a human transitional cell carcinoma (grade II) originating from a bladder cancer metastasis (lymph) of a 26-year old male. Tumourigenicity studies in nude mice revealed the UM-UC-1 produced tumours, 1-1.5 cm in diameter in < 3 weeks. UM-UC-1 showed strong over expression of nuclear staining for p53 by immunochemical analysis. UM-UC-1 was more resistant to adenoviral gene transduction than several of the other cells evaluated. This cell line has one of the highest levels of coxsackie adenovirus receptor (CAR) expression of the cells tested. UM-UC-1 is among a panel of 11 human urothelial cancer cell lines deposited by the University of Michigan.
Alternate name: UM-UC-1; UMUC1; University of Michigan-Urothelial Carcinoma-1
Cellosaurus ID: CVCL_2743
Disease: Cancer
Cat. #: 160436
Unit size: 1×10^6 cells / vial
Cancer types: Bladder cancer
Research Fields: Cancer
Organism: Human
Tissue: Lymphatic Tissue
Model: Tumourigenic cell line
Growth properties: Adherent
Cancer Types In Detail: Human bladder translational cell carcinoma
Format: Frozen
Shipping conditions: Dry ice
Growth medium: Cells were grown in MEM + 1% NEAA + 2mM Glutamine + 10% Foetal Bovine Serum (FBS).
Subculture routine: Split sub confluent cultures (70-80%) 1:4 to 1:10 i.e. seeding at 2-4×10,000 cells/cm2; using 0.05% trypsin or trypsin/EDTA; 5% CO2, 37°C. Doubling time approximately 26 hours.
References:

Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.

Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.

Images

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UM-UC-1 Cell Line - growth profile. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)
UM-UC-1 Cell Line. 24 hour post resuscitation. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)

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