JIM1 Cell Line

A human multiple myeloma model widely used to study DNA mismatch repair deficiency, genomic instability, and therapeutic development.

Contributors

Inventor Institute
M.S. Hamilton University of Birmingham
SKU: 151449
Product description: JIM1 shows typical plasma cell phenotype (CD38, PCA-1 8A and CD24 positive), deficient in DNA repair.
Alternate name: JIM-1; jim1
Gender: Female
Conditional: Yes
Production details: Derived from plasma myeloma cells from pleural fluid of advanced multiple myeloma female patient.
Cellosaurus ID: CVCL_2532
Disease: Cancer
Cat. #: 151449
Tool sub type: Primary
Unit size: 1×10^6 cells / vial
Cancer types: Blood cancer
Research Fields: Cancer;Drug development;Genetics
Organism: Human
Tissue: Blood
Gender: Female
Model: Tumour line
Growth properties: Suspension
Cancer Types In Detail: Human multiple myeloma
Format: Frozen
Shipping conditions: Dry ice
Growth medium: Dexter culture medium, consisting of Fischer's medium + 20% FCS +10-7 M hydrocortisone sodium succinate. Seed at 2-9 x 10 5 cells/cm3 5% CO2; 37 °C
References:

Brito et al. 2009. Haematologica. 94(1):78-86. PMID: 19059936.

Leone et al. 2008. Clin Cancer Res. 14(19):6033-6041. PMID: 18829482.

Velangi et al. 2004. Carcinogenesis. 25(10):1795-1803. PMID: 15142887.

Hamilton et al. 1991. Leukemia. 5(9):768-771. PMID: 1943229.

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