DLKP-A10 cell line

The MDR variant of the human lung cell lines DLKP. DLKP-A10 overexpresses the MDR associated P-glycoprotein efflux pump

Contributors

Inventor Institute
Martin Clynes Dublin City University
Cat. #: 161752
Cancer types: Lung cancer
Research Fields: Cancer
Organism: Human
Tissue: Lung
Morphology: Monolayer
Primary citation: Clary et. al. Biochemical Pharmacology, 1997 53(10): 1493-1502. PMID: 9260877
Product description: DLKP-A10 is a drug-resistant subpopulation of DLKP squamous carcinoma cell line. It overexpresses the MDR associated P-glycoprotein efflux pump.
CRISPR: No
Production details: DLKP-A was established by continuous exposure of the DLKP cells (pDLKP) to escalating concentrations of Adr (Step 1: 0.05 ?g/mL–0.8 ?g/mL Adr for 11 months, Step 2: 0.8 ?g/mL–1.75 ?g/mL for 3 months and Step 3: 1.75 ?g/mL–2.1 ?g/mL for 3 months)
Parental cell line: DLKP cell line
Disease: Cancer
Products or characteristics of interest: The cell line exhibits various levels of resistance to chemotherapeutic agents
Storage conditions: Liquid Nitrogen
Shipping conditions: Dry ice
Growth medium: DMEM-F12 medium supplemented with 5% FBS and 1% L-glutamine
Temperature: 37° C
Atmosphere: 5% CO2
Mycoplasma free: Yes
References:

Clary et. al. Biochemical Pharmacology, 1997 53(10): 1493-1502. PMID: 9260877

Efeoglu et. al. Biomolecules. 2022 Oct 1,12(10):1401. PMID: 36291610

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