Carbazole derivative HV-118

Compounds of the derivatives potentially inhibit Rac1 and Cdc42 Rho GTPases in cancer and metastasis signalling pathways

Contributors

Inventor Institute
Cornelis Vlaar University of Puerto Rico
Cat. #: 161688
Research Fields: Cancer
Application: Cancer research, anti-metastatic therapeutics development, potential treatment for other hyperproliferative diseases associated with Rac1 and Cdc42
Purpose: Designed to mimic the 'U-shaped' conformation adopted by EHop-016 as it binds Rac1
Primary citation: Vlaar et al. Bioorg Med Chem. 26(4): 884-890 PMID: 29358027
Product description: Carbazole derivative HV-118 is a highly potent novel anti-cancer and anti-metastatic carbazole derivative. Carbozole derivatives based on EHop-016 generated to mimic the ‘U-shaped’ conformation adopted by EHop-016 as it binds Rac2
Primary target: Rac
References:

Vlaar et al. Bioorg Med Chem. 26(4): 884-890 PMID: 29358027

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