Biotinylated medium chain polyphosphate small molecule (tool compound)

The biotinylated medium chain polyphosphate is linear polymers of inorganic orthophosphate linked by high-energy phosphoanhydride bonds that has an approximate polymer length ranging from 45-160 phosphate units. This polyphosphate has covalently attached biotin to one or both terminal phosphates of the polyphosphate chain. Biotinylated polyphosphate can be immobilized on streptavidin-coated multiwell plates or beads for […]

Contributors

Inventor Institute
James Morrissey University of Michigan
Product description: The biotinylated medium chain polyphosphate is linear polymers of inorganic orthophosphate linked by high-energy phosphoanhydride bonds that has an approximate polymer length ranging from 45-160 phosphate units. This polyphosphate has covalently attached biotin to one or both terminal phosphates of the polyphosphate chain. Biotinylated polyphosphate can be immobilized on streptavidin-coated multiwell plates or beads for binding studies. Polyphosphates are secreted from platelets to regulate blood clotting and have been used in plasma clotting assays and to study bacteria growth and function.
References:

Wang et al. 2019. J Thromb Haemost. :. PMID: 31420909.

Zilberman-Rudenko et al. 2018. Arterioscler Thromb Vasc Biol. 38(8):1748-1760. PMID: 30354195.

Wijeyewickrema et al. 2016. Blood. 128(13):1766-76. PMID: 27338096.

Choi et al. 2015. Thromb Haemost. 113(3):599-604. PMID: 25338662.

Puy et al. 2013. J Thromb Haemost. 11(7):1341-52. PMID: 23659638.

Smith et al. 2012. Blood. 120(26):5103-10. PMID: 22968458.

Choi et al. 2011. Blood. 118(26):6963-70. PMID: 21976677.

Smith et al. 2010. Blood. 116(20):4353-9. PMID: 20709905.

Choi et al. 2010. Biochemistry. 49(45):9935-41. PMID: 20957999.

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