p53Lck-TLX1 Mouse

This model organism recapitulates many molecular features of human leukaemia<U+0092>s induced by the TLX family of TF oncogenes.

Contributors

Inventor Institute
Adolfo Ferrando The Trustees of Columbia University in the City of New York
Cat. #: 154093
Research Fields: Cancer;Immunology
Target: TLX1
disease: T cell acute lymphoblastic leukemia
Model: Transgenic
Strain: C57BL/6
Alternate name: T Cell Leukemia Homeobox 1, Homeo Box-11, Proto-Oncogene TCL-3, HOX11, TCL3
Product description: TLX1 is an orphan homeobox gene. It was originally discovered in association with 4-7% of cases of T cell acute lymphoblastic leukaemias harbouring a t(10;14)(q24;q11) cytogenetic abnormality. Research showed the presence of the TLX1 gene on chromosome 10q24 juxtaposed with the T cell receptor (TCR) delta regulatory elements on chromosome 10, resulting in aberrant over-expression of the full and intact TLX1 gene. Juxtaposition with the TCR alpha locus was also seen. Elevated TLX1 expression in leukemic blasts is also detected in the absence of a translocation in ~50% (37/76) of paediatric T-ALL cases, as well as rare cases of B-AL. Clinically, TLX1+ T-ALLs are associated with a genetic signature associated with maturation arrest at an early cortical thymocyte stage of T cell development. This model organism recapitulates many molecular features of human leukaemias induced by the TLX family of TF oncogenes.
Conditional: No
Genetic background: The human TLX1 cDNA was amplified by PCR using BamHI restriction site containing primers and cDNA of the human T-cell leukemia cell line ALL-SIL as template and was cloned in the pUC1017 vector, downstream of the mouse T-cell specific p56Lck proximal promoter
Production details: The human TLX1 cDNA was amplified by PCR using BamHI restriction site containing primers and cDNA of the human T-cell leukemia cell line ALL-SIL as template and was cloned in the pUC1017 vector, downstream of the mouse T-cell specific p56Lck proximal promoter
Additional notes: Transgenic mouse expressing human transcription factor Tlx1 in T cell progenitors under control of the LCK promoter
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

De Keersmaecker et al. 2010. Nat Med. 16(11):1321-7. PMID: 20972433.

The TLX1 oncogene drives aneuploidy in T cell transformation.

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