Cat. #160590
Monocyte Chemoattractant Protein-1-Induced Protein-1 (MCPIP1) knockout mouse
Cat. #: 160590
Sub-type: Mouse
Availability: 6-8 weeks
Disease: Human primary biliary cholangitis
Model: Knock-Out
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Contributor
Inventor: Jerzy Kotlinowski ; Natalia Pydyn ; Edyta Kus ; Stefan Chlopicki ; Jolanta Jura
Institute: Jagiellonian University
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: Monocyte Chemoattractant Protein-1-Induced Protein-1 (MCPIP1) knockout mouse
- Alternate name: Regnase1, Zc3h12a
- Tool sub type: Mouse
- Disease: Human primary biliary cholangitis
- Model: Knock-Out
- Description: Adapted from Kotlinowski J. et al. bioRxiv; 2020. DOI: 10.1101/2020.09.05.250522: Primary biliary cholangitis (PBC) is an autoimmune disease characterized by progressive destruction of the intrahepatic bile ducts. The immunopathology of PBC involves excessive inflammation; therefore, negative regulators of inflammatory response, such as Monocyte Chemoattractant Protein-1-Induced Protein-1 (MCPIP1, alias Regnase1) may play important roles in the development of PBC.
- Phenotype: Adapted from Kotlinowski J. et al. bioRxiv; 2020. DOI: 10.1101/2020.09.05.250522:This mouse model was developed to verify whether Mcpip1 expression protects against development of PBC. Deletion of hepatic Mcpip1 in Mcpip1AlbKO mice leads to development of PBC that recapitulates phenotype of human patients. These animals, show early prenatal origin and age-dependent progression of the disease.
- Additional notes: Adapted from Kotlinowski J. et al. bioRxiv; 2020. DOI: 10.1101/2020.09.05.250522: This mouse model was developed to verify whether Mcpip1 expression protects against development of PBC. Deletion of hepatic Mcpip1 in Mcpip1AlbKO mice leads to development of PBC that recapitulates phenotype of human patients. These animals, show early prenatal origin and age-dependent progression of the disease.
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: Monocyte Chemoattractant Protein-1-Induced Protein-1
References
- Deletion of Mcpip1 in Mcpip1AlbKO mice recapitulates the phenotype of human primary biliary cholangitis
