#156430

Kidney epithelial cell specific Keap1-deficient (Ksp-Keap1-KO) mouse

Cat. #156430

Kidney epithelial cell specific Keap1-deficient (Ksp-Keap1-KO) mouse

Cat. #: 156430

Sub-type: Mouse

Availability: 6-8 weeks

Disease: Acute Kidney Injury and Chronic Kidney Disease

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Contributor

Inventor: Hamid Rabb

Institute: Johns Hopkins University

Tool Details
Target Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: Kidney epithelial cell specific Keap1-deficient (Ksp-Keap1-KO) mouse
  • Research fields: Drug development
  • Tool sub type: Mouse
  • Disease: Acute Kidney Injury and Chronic Kidney Disease
  • Description: This model helps elucidate a novel kelch-like ECH-associated protein 1 (KEAP 1) mediated signaling pathway in renal development. The Nrf2-Keap1 pathway has an important role in both acute kidney injury (AKI) and chronic kidney disease (CKD). This pathway has a key regulatory function on many antioxidant and stress pathways, including heme oxygenase. This model has allowed for the indetification of KEAP 1 as factor involved in cyst formation and hydronephrosis during kidney development, which is advantageous for; studying kidney development as well as the role of the KEAP 1 pathway in kidney repair and regeneration.
  • Genetic background: Keap1F/F mice crossed with CD4-Cre mice.

Target Details

  • Target: Keap1

References

  • Noel et al. 2015. J Am Soc Nephrol. 26(12):2989-3000. PMID: 26293820.