Integrin a6b4 Mouse

Chemically-induced skin tumourigenesis model; in vivo study of alpha6 and beta4 integrin transgene expression in skin.

Contributors

Inventor Institute
Fiona Watt Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151550
Cancer types: Skin cancer
Research Fields: Cancer;Cell biology;Cell signaling and signal transduction;Genetics;Stem cell biology
Target: Alpha6Beta4 Integrin
disease: Cancer
Zygosity: Heterozygous
Phenotype: Mice present phenotype very similar to human psoriasis disease.
Product description: Chemically-induced skin tumourigenesis model; in vivo study of alpha6 and beta4 integrin transgene expression in skin. Ninety six percent of alpha6beta4 transgenic mice develop squamous cell carcinoma, compared to 44% wildtype. Of those mice developing tumours, 68% alpha6beta4 develop metastasis, compared to 8% wildtype. TGF-beta signalling is disrupted in alpha6beta4 transgenic mice.
Conditional: Yes
Conditional description: Conditional expression of integrins under involucrin promoter giving tissue-specific suprabasal epidermal expression.
Genetic background: Involucrin – integrin transgene expression constructs were injected into fertilized oocytes from F1 hybrid CBAxC57Bl/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. alpha6 founder line was crossed with beta4 founder line to generate alpha6beta4 line.
Production details: Involucrin – integrin transgene expression constructs were injected into fertilized oocytes from F1 hybrid CBAxC57Bl/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. alpha6 founder line was crossed with beta4 founder line to generate alpha6beta4 line.
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Owens DM et al, Journal of Cell Science, 2003, v116 pp3783-3791PMID: 12902406

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