Cat. #156430
Kidney epithelial cell specific Keap1-deficient (Ksp-Keap1-KO) mouse
Cat. #: 156430
Sub-type: Mouse
Availability: 8-10 weeks
Disease: Acute Kidney Injury and Chronic Kidney Disease
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Hamid Rabb
Institute: Johns Hopkins University
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: Kidney epithelial cell specific Keap1-deficient (Ksp-Keap1-KO) mouse
- Research fields: Drug development
- Tool sub type: Mouse
- Disease: Acute Kidney Injury and Chronic Kidney Disease
- Description: This model helps elucidate a novel kelch-like ECH-associated protein 1 (KEAP 1) mediated signaling pathway in renal development. The Nrf2-Keap1 pathway has an important role in both acute kidney injury (AKI) and chronic kidney disease (CKD). This pathway has a key regulatory function on many antioxidant and stress pathways, including heme oxygenase. This model has allowed for the indetification of KEAP 1 as factor involved in cyst formation and hydronephrosis during kidney development, which is advantageous for; studying kidney development as well as the role of the KEAP 1 pathway in kidney repair and regeneration.
- Genetic background: Keap1F/F mice crossed with CD4-Cre mice.
Target Details
- Target: Keap1
References
- Noel et al. 2015. J Am Soc Nephrol. 26(12):2989-3000. PMID: 26293820.
