JamC -/- Mouse

In vivo study of JAM-C knockout; in vivo study of spermiogenesis; in vivo study of neuronal networks and integrity

Contributors

Inventor Institute
Ralf H. Adams Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151562
Research Fields: Cancer;Cell signaling and signal transduction;Genetics;Neurobiology
Target: Junctional adhesion molecule-C (JAM-C)
disease: Neuropathy
Model: Knock-Out
Zygosity: Heterozygous
Phenotype: Mice are maintained as heterozygotes (JamC+/-) to permit breeding (due to male fertility defects in JamC-/- mice).
Product description: In vivo study of JAM-C knockout; in vivo study of spermiogenesis; in vivo study of neuronal networks and integrity
Conditional: No
Production details: A JamC targeting vector, containing loxP flanked exons 4, 5, and a cDNA encoding exons 6 to 9, an exon 4 – reporter fusion, and a frt flanked resistance cassette, was injected into E14 ES cells. Properly targeted ES cells containing a homologous recombination event were selected, cloned, and injected into C57BL6 blastocysts. Chimeric offspring were mated to C57BL6 mice, and floxed JamC lines maintained on a mixed 129/C57BL6 background. Floxed JamC mice were crossed with Cre expressing mice to generate heterozygous JamC+/- mice. Heterozygous JamC+/- mice were interbred to generate JamC-/- mice.
Additional notes: Mice are maintained as heterozygotes (JamC+/-) to permit breeding (due to male fertility defects in JamC-/- mice).
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Gliki et al. 2004. Nature. 431(7006):320-4. PMID: 15372036.

Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C.

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