#151444

InvEE Mouse

Cat. #151444

InvEE Mouse

Cat. #: 151444

Sub-type: Mouse

Availability: 6-8 weeks

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Fiona Watt

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details
Handling
Target Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: InvEE Mouse
  • Research fields: Cell signaling and signal transduction;Genetics
  • Tool sub type: Mouse
  • Conditional: Yes
  • Conditional description: Conditional expression of MEK1 under involucrin promoter giving tissue-specific suprabasal epidermal expression.
  • Description: A transgenic mouse expressing constitutively active MEK 1 in the epidermis. The mouse displays many phenotypes associated with psoriasis including abnormal keratinocyte differentation, hyperproliferation of keratinocytes and infiltration of inflammatory elements. Disease model for psoriasis; in vivo study of constituitively active murine MEK1 mutant (S217E/S221E) in skin.
  • Genetic background: An involucrin - MEK1 transgene expression construct was injected into male pronucleus of fertilized F1 hybrid CBAxC57Bl/6 embryos. Transgene-positive mice were mated with wildtype F1 CBAxC57BL/6 to generate founder lines.
  • Production details: An involucrin - MEK1 transgene expression construct was injected into male pronucleus of fertilized F1 hybrid CBAxC57Bl/6 embryos. Transgene-positive mice were mated with wildtype F1 CBAxC57BL/6 to generate founder lines.

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Target Details

  • Target: MEK1

References

  • Carroll et al. 1995. Cell. 83(6):957-68. PMID: 8521519.
  • Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis.