InvEE Mouse

A transgenic mouse expressing constitutively active MEK 1 in the epidermis.

Contributors

Inventor Institute
Fiona Watt Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151444
Research Fields: Cell signaling and signal transduction;Genetics
Target: MEK1
Product description: A transgenic mouse expressing constitutively active MEK 1 in the epidermis. The mouse displays many phenotypes associated with psoriasis including abnormal keratinocyte differentation, hyperproliferation of keratinocytes and infiltration of inflammatory elements. Disease model for psoriasis; in vivo study of constituitively active murine MEK1 mutant (S217E/S221E) in skin.
Conditional: Yes
Conditional description: Conditional expression of MEK1 under involucrin promoter giving tissue-specific suprabasal epidermal expression.
Genetic background: An involucrin – MEK1 transgene expression construct was injected into male pronucleus of fertilized F1 hybrid CBAxC57Bl/6 embryos. Transgene-positive mice were mated with wildtype F1 CBAxC57BL/6 to generate founder lines.
Production details: An involucrin – MEK1 transgene expression construct was injected into male pronucleus of fertilized F1 hybrid CBAxC57Bl/6 embryos. Transgene-positive mice were mated with wildtype F1 CBAxC57BL/6 to generate founder lines.
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Carroll et al. 1995. Cell. 83(6):957-68. PMID: 8521519.

Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis.

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