UNG Mouse

In vivo study of UNG knockout and DNA mismatch mutation during DNA synthesis. Mice develop B cell lymphoma and are abnormally defective in their immune response. There are also mouse embryonic fibroblasts from this line available.

Contributors

Inventor Institute
Tomas Lindahl Cancer Research UK, London Research Institute: Clare Hall Laboratories
Cat. #: 151556
Cancer types: Blood cancer
Research Fields: Cancer;Genetics;Immunology
Target: Uracil-DNA Glycosylase (UNG)
disease: Cancer
Zygosity: Homozygous
Product description: In vivo study of UNG knockout and DNA mismatch mutation during DNA synthesis. Mice develop B cell lymphoma and are abnormally defective in their immune response. There are also mouse embryonic fibroblasts from this line available.
Conditional: No
Production details: A ung targeting vector, replacing exon 4 with a resistance cassette, was transfected into 129 ES cells. Properly targeted ES cells containing a homologous recombination event were selected, cloned, and injected into C57BL6 blastocysts. Chimeric mice were mated with C57BL6 mice to generate heterozygotes. Heterozygous mice were crossed to generate homozygous Ung-/- mice.
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Nilsen et al. 2003. Oncogene. 22(35):5381-6. PMID: 12934097.

Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas.

Nilsen et al. 2000. Mol Cell. 5(6):1059-65. PMID: 10912000.

Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication.

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