UM-UC-11 (Human transitional cell carcinoma of the bladder) cell line

UM-UC-11 is a human transitional cell carcinoma cell line that is non-tumorigenic in nude mice. This cell line demonstrates efficient gene transduction capabilities. The UM-UC panel of urothelial carcinoma is a diverse range of 11 patient derived cell lines developed by the university of Michigan that have been well-categorised in the literature. These cells were assessed for their susceptibility to adenoviral mediated gene delivery, tumour growth in nude mice and differences in genetic alterations.

Contributors

Inventor Institute
H. Grossman ; Anita Sabichi University of Michigan
Cat. #: 160441
Unit size: 1×10^6 cells / vial
Cancer types: Genitourinary cancer
Research Fields: Cancer
Organism: Human
Tissue: Bladder
Model: Tumour cell line
Growth properties: Adherent
Cancer Types In Detail: Human bladder transitional cell carcinoma
Alternate name: UM-UC-11; UM-UC11; UMUC11; UC-11; University of Michigan-Urothelial Carcinoma-11
Product description: UM-UC-11 is a human transitional cell carcinoma cell line that is non-tumorigenic in nude mice. This cell line demonstrates efficient gene transduction capabilities. The UM-UC panel of urothelial carcinoma is a diverse range of 11 patient derived cell lines developed by the university of Michigan that have been well-categorised in the literature. These cells were assessed for their susceptibility to adenoviral mediated gene delivery, tumour growth in nude mice and differences in genetic alterations.
Conditional: Yes
disease: Cancer
Format: Frozen
Shipping conditions: Dry ice
Growth medium: EMEM (EBSS) + 2mM Glutamine + 1% Non Essential Amino Acids (NEAA) + 10% Foetal Bovine Serum (FBS).
Subculture routine: Split sub-confluent cultures (70-80%) 1:3 to 1:6 i.e. seeding at 2-4×10,000 cells/cm2; using 0.05% trypsin/EDTA; 5% CO2; 37°C
References:

Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.

Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.

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