#153292

Sdhb -/- CL 5 Cell Line

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Cat. #153292

Sdhb -/- CL 5 Cell Line

Cat. #: 153292

Unit size: 1x10^6 cells / vial

Availability: 3-4 weeks

Organism: Mouse

Tissue: Kidney

Disease: Cancer

Model: Knock-Out

£575.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Eyal Gottlieb

Institute: Cancer Research UK, Glasgow: The Beatson Institute

Tool Details
Target Details
Handling
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Sdhb -/- CL 5 Cell Line
  • Alternate name: Succinate dehydrogenase, SDH, Succinate-coenzyme Q reductase, SQR
  • Research fields: Cancer;Drug development;Metabolism
  • Organism: Mouse
  • Tissue: Kidney
  • Disease: Cancer
  • Model: Knock-Out
  • Description: Succinate dehydrogenase (SDH) is an enzyme complex found in the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells. SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle. The enzymatic function of SDH oxidises succinate to fumarate in the tricarboxylic acid cycle and losing this function is associated with cancer formation.
  • Biosafety level: 1
  • Cellosaurus id: CVCL_HG12

Target Details

  • Target: Succinate dehydrogenase

Handling

  • Format: Frozen
  • Unit size: 1x10^6 cells / vial
  • Shipping conditions: Dry ice
  • Storage conditions: Liquid Nitrogen
  • Mycoplasma free: Yes

Related Tools

  • Related tools: SDHB Floxed Mouse ; Sdhb -/- CL 7 Cell Line ; Sdhb fl/fl Cell Line

References

  • Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.
  • Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.