#162030

Melan-p2 cell line

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Cat. #162030

Melan-p2 cell line

Cat. #: 162030

Organism: Mouse

Tissue: Skin

Disease: Ocular Albanism

Model: Immortalised non-cancerous cell lines

£575.00

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Contributor

Inventor: Elena Sviderskaya

Institute: St. George's University London

Primary Citation: Sviderskaya EV, et al. J Invest Dermatol.1997 Jan;108(1):30-4. PMID: 8980282

Tool Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Melan-p2 cell line
  • Organism: Mouse
  • Tissue: Skin
  • Disease: Ocular Albanism
  • Morphology: Small, oval-fusiform
  • Model: Immortalised non-cancerous cell lines
  • Description: The melan-p1 and -p2 cell lines are immortal melanocyte cell lines derived from neonatal Oca2p-cp/Oca2p-25H CH3 mice. These cell lines lack Oca2 (also referred to a p protein), a chloride ion channel found to relate melanosomal pH. Pathogenic variants in the human ortholog of Oca2, OCA2, result in oculocutaneous albinism type 2, a form of albinism characterised by variable hypopigmentation of the skin and hair and ocular defects. Individuals with OCA2 have significantly higher risk of developing skin cancers, including melanoma. These cells are hypopigmented despite the expression of tyrosinase. These cells are a useful model for OCA2 and for use in pigment cell biology studies. Melanoblast lines (melb-p3 and melb-p4) derived from pcp/p25H C3H mice are also available from CancerTools.org.
  • Application: Melanocyte cell biology

Applications

  • Application: Melanocyte cell biology

Handling

  • Storage conditions: liquid N2

References

  • Sviderskaya EV, et al. J Invest Dermatol.1997 Jan
  • 108(1):30-4. PMID: 8980283