Cat. #162014
Melan-In1 cell line
Cat. #: 162014
Organism: Mouse
Tissue: Skin
Disease: Non-cancer
Model: Immortalised non-cancerous cell lines
£575.00
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Contributor
Inventor: Elena Sviderskaya
Institute: St. George's University London
Tool Details
*FOR RESEARCH USE ONLY
- Name: Melan-In1 cell line
- Organism: Mouse
- Tissue: Skin
- Disease: Non-cancer
- Morphology: Small, oval-fusiform
- Model: Immortalised non-cancerous cell lines
- Description: The melan-ln1, -ln2, ln-3 and ln-4 lines are immortal melanocyte cell lines derived from the skin of neonatal Mlphln/Mlphln null Ink4aArf -/- C57BL6/J mice. The leaden gene product (melanophilin, Mlph) is a Rab27a effector protein involved in melanosome transport and as such, these leaden null melanocytes display perinuclear clustering of pigmented melanosomes. These murine melanocytes are a model of the human disorder Griscelli syndrome in which patients present with hypopigmented skin and hair and immunodeficiencies. These melanocytes are a useful tool for studies of pigmentation genetics and transport of photoprotective eumelanin.
- Application: Melanocyte cell biology
Applications
- Application: Melanocyte cell biology
Handling
- Growth medium: RPMI + FBS (10%) + TPA (200 nM) + cholera toxin (CT) (200 pM)
- Storage conditions: liquid N2
