A2EN human epithelial cell line

The A2EN human epithelial cell line is an immortalized epithelial cell line originating from an endocervical tissue explant that can be polarized to exhibit distinct apical and basolateral membrane domains. Polarized A2EN cells maintain phenotypic and functional characteristics of the epithelial endocervix cells including secreting mucus and expressing MUC5B, hormone receptors, anti-microbial peptides (AMPs) and […]

Contributors

Inventor Institute
Alison Quayle Louisiana Sate University (LSU) Health Sciences Center New Orleans
Cat. #: 157949
Unit size: 1×10^6 cells / vial
Research Fields: Tissue-specific biology
Organism: Human
Tissue: Cervix
Model: Immortalised Line
Product description: A2EN is an immortalized epithelial cell line originating from an endocervical tissue explant that can be polarized to exhibit distinct apical and basolateral membrane domains. Polarized A2EN cells maintain phenotypic and functional characteristics of the epithelial endocervix cells including secreting mucus and expressing MUC5B, hormone receptors, anti-microbial peptides (AMPs) and pro-inflammatory cytokines and chemokines. This in vitro model can be used in sexually transmitted infections and topical microbicides research.
Format: Frozen
Shipping conditions: Dry ice
References:

Buckner LR, et al. J Reprod Immunol. 2011 Dec92(1-2):8-20. PMID: 21943934

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