Cat. #154235
2C4 cell line
Cat. #: 154235
Sub-type: Continuous
Unit size: 1x10^6 cells / vial
Availability: 8-10 weeks
Organism: Human
Disease: Cancer
£575.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: George Stark ; Ian Kerr
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: 2C4 cell line
- Cancer: Sarcoma
- Cancers detailed: Fibrosarcoma
- Research fields: Cancer;Cell signaling and signal transduction;Immunology
- Tool sub type: Continuous
- Parental cell: HT 1080
- Organism: Human
- Disease: Cancer
- Description: The 2C4 cell line is a clonal derivative of the human fibrosarcoma cell line HT 1080. The 2C4 cell line clone expresses the simple cell-surface marker CD2 (normally expressed only on T cells) under the control of the 9-27 gene promoter. The 9-27 gene promoter is inducible by interferon gamma.
- Biosafety level: 1
- Cellosaurus id: CVCL_1D50
Handling
- Format: Frozen
- Growth medium: DMEM + 10% heat-inactivated FBS + 400ug G418 per ml (As described by Kohlhuber et al., 1997)
- Unit size: 1x10^6 cells / vial
- Shipping conditions: Dry ice
- Storage conditions: Liquid Nitrogen
- Mycoplasma free: Yes
Related Tools
- Related tools: Gamma2A Jak2 Cell Line ; 2C4-Gamma2A cell line
References
- Kohlhuber et al. 1997. Mol Cell Biol. 17(2):695-706. PMID: 9001223.
- A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.
- Watling et al. 1993. Nature. 366(6451):166-70. PMID: 7901766.
- Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.
