Antibody to Dimethyl K-PhosphoS Histone H3. The generated 51TA2H12 clone recognizes S10- or S28-phosphorylated histone H3, but only when doubly modified with H3K9me2 or H3K27me2 (see reference).Specificity: dimethylated (K9)-phosphorylated (S10) histone H3 or dimethylated (K27)- phosphorylated (S28) histone H3. These histone H3 modifications are correlated with mitosis.
| Institute |
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| Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) |
| Cat. #: | 162412 |
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| Research Fields: | Epigenetics and Nuclear signalling |
| Application: | ELISA, WB, IF, immunoprecipitation |
| Target: | Dimethyl K-PhosphoS Histone H3 |
| Reactivity: | Sequence conserved in wide range of species |
| Clone: | 51TA-2H12 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Eberlin et al. (2008). Mol Cell Biol. 28(5):1739-54. PMID: 18180282 |
| Product description: | Antibody to Dimethyl K-PhosphoS Histone H3. The generated 51TA2H12 clone recognizes S10- or S28-phosphorylated histone H3, but only when doubly modified with H3K9me2 or H3K27me2 (see reference).Specificity: dimethylated (K9)-phosphorylated (S10) histone H3 or dimethylated (K27)- phosphorylated (S28) histone H3. These histone H3 modifications are correlated with mitosis. |
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| Additional notes: | Avoid repeat freezing and thawing cycles. Does not contain any preservative. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1, K |
| Immunogen: | Ovalbumin conjugated synthetic peptide ASGSSRSKS[dimethyl K]DRKYTL(C) corresponding to aa 180-195 of human TAF10. |
| Target background: | Histone H3 is both dimethylated on a lysine and phosphorylated on a serine, a combination of modifications that can have specific effects on chromatin and gene regulation in cancer. |
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| Storage conditions: | -20°C (up to 3 years) |
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| References: |
Eberlin et al. (2008). Mol Cell Biol. 28(5):1739-54, PMID: 18180282 |
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