Creatine Kinase B (CK-BYK) [2E10]

Creatine kinase, also known as creatine phosphokinase or phosphocreatine kinase, is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate to create phosphocreatine and adenosine diphosphate. Subcellular partitioning of creatine kinase contributes to the formation of patterns in intracellular ATP distribution and the fuelling of […]

Contributors

Inventor Institute
BĂŠ Wieringa Radboud University Medical Centre
Cat. #: 160393
Unit size: 100 ug
Research Fields: Cell biology;Metabolism;Neurobiology
Application: WB ; EM ; IHC ; IF ; WB
Target: Brain-type creatine kinase
Reactivity: Human ; Mouse ; Rat ; Rabbit
Host: Mouse
Class: Monoclonal
Alternate name: CKBB, creatine phosphokinase, phosphocreatine kinase
Product description: Creatine kinase, also known as creatine phosphokinase or phosphocreatine kinase, is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate to create phosphocreatine and adenosine diphosphate. Subcellular partitioning of creatine kinase contributes to the formation of patterns in intracellular ATP distribution and the fuelling of cellular processes with a high and sudden energy demand. We have previously shown that brain-type creatine kinase (CK-B) accumulates at the phagocytic cup in macrophages where it is involved in the compartmentalized generation of ATP for actin remodeling.
Conjugation: Unconjugated
Isotype: IgG2b
Immunogen: A synthetic 17-mer peptide corresponding to a unique sequence in the amino-terminal region of human creatine kinase B
Myeloma used: Sp2/0-Ag14
Target background: Creatine kinase, also known as creatine phosphokinase or phosphocreatine kinase, is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate to create phosphocreatine and adenosine diphosphate. Subcellular partitioning of creatine kinase contributes to the formation of patterns in intracellular ATP distribution and the fuelling of cellular processes with a high and sudden energy demand. We have previously shown that brain-type creatine kinase (CK-B) accumulates at the phagocytic cup in macrophages where it is involved in the compartmentalized generation of ATP for actin remodeling.
Format: Liquid
Shipping conditions: Dry ice
References:

Venter et al. 2015. Eur J Cell Biol. 94(2):114-27. PMID: 25538032.

Sistermans et al. 1995. Cell Tissue Res. 280(2):435-46. PMID: 7781040.

de Kok et al. 1995. Mol Cell Biochem. 143(1):59-65. PMID: 7776959.

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