X-Ray Repair Cross Complementing 2 (XRCC2) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC2 is […]
| Inventor | Institute |
|---|---|
| Stephen West | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151282 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics;Microbiology |
| Application: | WB |
| Target: | XRay Repair Cross Complementing 2 (XRCC2) |
| Reactivity: | Human ; Hamster |
| Clone: | XRCC2 1G4/1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | X-Ray Repair Cross Complementing 2 (XRCC2) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC2 is also a component of the homologous recombination pathway. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 33 kDa |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | X-Ray Repair Cross Complementing 2 (XRCC2) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC2 is also a component of the homologous recombination pathway. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Gildemeister et al. 2009. J Biol Chem. 284(46):31945-52. PMID: 19783859. Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C. Nagaraju et al. 2009. Mol Cell Biol. 29(15):4283-94. PMID: 19470754. XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversions between sister chromatids. French et al. 2002. J Biol Chem. 277(22):19322-30. PMID: 11912211. Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. |
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