Cardiac and skeletal muscle contraction involves the cyclic interaction of myosin cross bridges with actin involving the concomitant hydrolysis of Mg ATP. Troponin and tropomyosin, located on the actin thin filament, are responsible for the calcium dependent regulation of the contractile process by responding to changes in the intracellular free calcium concentration. Muscle contraction is […]
| Inventor | Institute |
|---|---|
| Peter Cummins | University Of Birmingham |
| Cat. #: | 160857 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Tissue-specific biology |
| Application: | ELISA ; WB |
| Target: | Human Cardiac Troponin 1 |
| Reactivity: | Human ; Dog |
| Clone: | 20 |
| Class: | Monoclonal |
| Alternate name: | CdTn1, cTn1 |
|---|---|
| Product description: | Cardiac and skeletal muscle contraction involves the cyclic interaction of myosin cross bridges with actin involving the concomitant hydrolysis of Mg ATP. Troponin and tropomyosin, located on the actin thin filament, are responsible for the calcium dependent regulation of the contractile process by responding to changes in the intracellular free calcium concentration. Muscle contraction is initiated by the binding of calcium to troponin C; this initiates a cascade of allosteric changes in the troponin/ tropomyosin complex, releasing the inhibitory troponin-I/actin interaction, and resulting in tropomyosin rotating radially on the thin filament from the inhibitory position. This allows actin and myosin to interact fully and, therefore, contraction to ensue. |
| Isotype: | IgG2a |
| Immunogen: | Canine and Human CdTn1 |
| Shipping conditions: | Dry ice |
|---|
| References: |
Al-Hillawi et al. 1998. Eur J Biochem. 256(3):535-40. PMID: 9780229. Cummins et al. 1987. Am Heart J. 113(6):1333-44. PMID: 3591601. |
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