Cat. #151289
Anti-TCR CBeta1 [JOVI.1] mAb
Cat. #: 151289
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 1-2 weeks
Target: TCR CBeta1
Class: Monoclonal
Application: WB ; FACS ; IHC ; IF ; IP
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Mike Owen
Institute: Cancer Research UK, Lincoln's Inn Fields Institute
Primary Citation: Viney et al. 1993. Hybridoma. 11(6):701-13. PMID: 1284120.
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-TCR CBeta1 [JOVI.1] mAb
- Research fields: Cell biology;Immunology
- Clone: JOVI.1
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Cell signalling pathway: TCR signalling
- Reactivity: Human
- Host: Mouse
- Application: WB ; FACS ; IHC ; IF ; IP
- Description: Monoclonal antibody specific for the variable region of T cell receptors in humans. This antibody aids the study of T-cell mediated diseases. Anti-TCR CBeta1 [JOVI.1] mAb recognises an epitope on the majority of TCRs. Anti-TCR CBeta1 [JOVI.1] mAb is capable of inducing proliferation of peripheral blood T cells.
- Immunogen: Human HA1.7 TCR beta chain expressed on transgenic mouse cells.
- Immunogen uniprot id: P01850
- Isotype: IgG2a
- Myeloma used: P3/NS1/1-Ag4.1
Target Details
- Target: TCR CBeta1
- Target background: The T cell receptor is expressed on all mature T cells. The T cell receptor is heterodimer of alpha/beta or gamma/delta chains, expressed on all mature T cells. TCR's recognize antigen peptides bound to MHC molecules, providing the basis of antigen specific response by T cells. Genetic mutations involving the T cell receptor beta locus have been associated with T cell lymphomas. JOVI.1 can be used for studies of T-cell mediated diseases, including autoimmunity and allergy. Antibody JOVI.1 recognised a determinant on the majority of TCRs, staining 50-75% of peripheral blood T cells and T cell lines expressing different V beta regions.
Applications
- Application: WB ; FACS ; IHC ; IF ; IP
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Shipping at 4° C
Related Tools
- Related tools: Anti-TCR C?1, Recombinant [JOVI.1]
References
- Rossatti et al. 2019. Cells. 8(11):1-13. PMID: 31690048.
- Beck et al. 2018. Hum Vaccin Immunother. 14(12):2864-2873. PMID: 30111232.
- Tesio et al. 2018. Hemasphere. 2(2):e38. PMID: 31723766.
- Risueño et al. 2008. PLoS ONE. 3(3):e1747. PMID: 18320063.
- Chen et al. 2007. J Biol Chem. 282(48):35361-72. PMID: 17897956.
- Gil et al. 2002. Cell. 109(7):901-12. PMID: 12110186.
- Viney et al. 1993. Hybridoma. 11(6):701-13. PMID: 1284120.
