Anti-TCR CBeta1 [JOVI.1] mAb

Monoclonal antibody which aids investigation into T-cell related diseases.

Contributors

Inventor Institute
Mike Owen Cancer Research UK, Lincoln's Inn Fields Institute
Cat. #: 151289
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell biology;Immunology
Application: WB ; FACS ; IHC ; IF ; IP
Target: TCR CBeta1
Reactivity: Human
Clone: JOVI.1
Host: Mouse
Class: Monoclonal
Primary citation: Viney et al. 1993. Hybridoma. 11(6):701-13. PMID: 1284120.
Product description: Monoclonal antibody specific for the variable region of T cell receptors in humans. This antibody aids the study of T-cell mediated diseases. Anti-TCR CBeta1 [JOVI.1] mAb recognises an epitope on the majority of TCRs. Anti-TCR CBeta1 [JOVI.1] mAb is capable of inducing proliferation of peripheral blood T cells.
Conjugation: Unconjugated
Isotype: IgG2a
Immunogen: Human HA1.7 TCR beta chain expressed on transgenic mouse cells.
Immunogen Uniprot ID: P01850
Myeloma used: P3/NS1/1-Ag4.1
Target background: The T cell receptor is expressed on all mature T cells. The T cell receptor is heterodimer of alpha/beta or gamma/delta chains, expressed on all mature T cells. TCR's recognize antigen peptides bound to MHC molecules, providing the basis of antigen specific response by T cells. Genetic mutations involving the T cell receptor beta locus have been associated with T cell lymphomas. JOVI.1 can be used for studies of T-cell mediated diseases, including autoimmunity and allergy. Antibody JOVI.1 recognised a determinant on the majority of TCRs, staining 50-75% of peripheral blood T cells and T cell lines expressing different V beta regions.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
Shipping conditions: Dry ice
References:

Rossatti et al. 2019. Cells. 8(11):1-13. PMID: 31690048.

Beck et al. 2018. Hum Vaccin Immunother. 14(12):2864-2873. PMID: 30111232.

Tesio et al. 2018. Hemasphere. 2(2):e38. PMID: 31723766.

Risueño et al. 2008. PLoS ONE. 3(3):e1747. PMID: 18320063.

Chen et al. 2007. J Biol Chem. 282(48):35361-72. PMID: 17897956.

Gil et al. 2002. Cell. 109(7):901-12. PMID: 12110186.

Viney et al. 1993. Hybridoma. 11(6):701-13. PMID: 1284120.

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