Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours.
| Inventor | Institute |
|---|---|
| Paul Crocker | University of Dundee |
| Cat. #: | 151199 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Immunology |
| Application: | ELISA ; FACS ; IHC ; RIA ; WB |
| Target: | Sialoadhesin domains 1-4 (SIGLEC1) |
| Reactivity: | Human |
| Clone: | HSn 7D2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CD169, Sialoadhesin 1 |
|---|---|
| Product description: | The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Fc fusion protein containing N-terminal 4 domains of human sialoadhesin. |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Puryear et al. 2013. PLoS Pathog. 9(4):e1003291. PMID: 23593001. Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169. Rempel et al. 2008. PLoS One. 3(4):e1967. PMID: 18414664. Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity. Pack et al. 2008. Immunology. 123(3):438-46. PMID: 17944899. DEC-205/CD205+ dendritic cells are abundant in the white pulp of the human spleen, including the border region between the red and white pulp. Hartnell et al. 2001. Blood. 97(1):288-96. PMID: 11133773. Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. Steiniger et al. 1997. Immunology. 92(2):307-16. PMID: 9415041. The species-specific structure of microanatomical compartments in the human spleen: strongly sialoadhesin-positive macrophages occur in the perifollicular zone, but not in the marginal zone. |
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