Antibody for the human primase p58, or human p58 protein kinase, of PRIM2. Applicable to numerous tumour types – its role in cancer is intimately linked to its essential function in DNA replication and genome maintenance.
| Institute |
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| Helmholtz Munich Core Facility Monoclonal Antibodies |
| Cat. #: | 162376 |
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| Tool sub type: | Primary antibody |
| Research Fields: | Cancer;Cell biology |
| Application: | WB |
| Target: | Human primase p58 |
| Reactivity: | Human |
| Clone: | PRI-5G6 |
| Host: | Rat |
| Class: | Monoclonal |
| Primary citation: | Weisshart et al. 2000. J. Biol. Chem. 275: 17328-17337. PMID: 10747950 |
| Alternate name: | Anti human primase p58 monoclonal antibody (clone PRI-5G6) |
|---|---|
| Product description: | Antibody for the human primase p58, or human p58 protein kinase, of PRIM2. Applicable to numerous tumour types – its role in cancer is intimately linked to its essential function in DNA replication and genome maintenance. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Recombinant primase p58 subunit |
| Target background: | Primase p58 (also known as PRIM2 or PriL) is a large regulatory subunit of DNA primase, an enzyme crucial for DNA replication in eukaryotes. DNA primase, in complex with DNA polymerase alpha, synthesizes short RNA primers that are essential for initiating new DNA strands on both the leading and lagging strands during DNA replication. |
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| References: |
Weisshart et al. 2000. J. Biol. Chem. 275: 17328-17337. PMID: 10747950 |
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