Monoclonal antibody which binds PCNA, a tumour proliferation marker.
| Inventor | Institute |
|---|---|
| Helle Ulrich | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151456 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Other |
| Research Fields: | Cancer;Cell biology;Genetics |
| Application: | WB ; ELISA ; IP ; WB |
| Target: | Proliferating cell nuclear antigen, (PCNA), also known as cyclin or polymerase delta accessory protein. |
| Reactivity: | Saccharomyces cerevisiae |
| Clone: | 5E6/2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Monoclonal antibody which binds PCNA, a tumour proliferation marker. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 30 kDa |
| Immunogen: | Purified recombinant His6-POL30 (PCNA) from budding yest, Saccharomyces cerevisiae, produced in Escherichia coli |
| Immunogen Uniprot ID: | P12004 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Monoclonal antibody which binds PCNA, a tumour proliferation marker. Background and Research Application PCNA, also known as polymerase delta auxiliary protein, is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. It is required for cellular DNA synthesis, and in vitro replication of SV40 DNA. It helps to co-ordinate the leading and lagging strand synthesis at the replication fork. PCNA binds to the CDK inhibitor p21, the structure-specific endonucle… |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Paul Solomon Devakumar et al. 2019. Nucleic Acids Res. 47(13):6826-6841. PMID: 31114918. Schalbetter et al. 2015. Proc Natl Acad Sci U S A. 112(33):E4565-70. PMID: 26240319. Kubota et al. 2011. Mol Cell Proteomics. 10(7):M110.005561. PMID: 21505101. Quantitative proteomic analysis of chromatin reveals that Ctf18 acts in the DNA replication checkpoint. Parker et al. 2008. EMBO J. 27(18):2422-31. PMID: 18701921. SUMO modification of PCNA is controlled by DNA. Davies et al. 2008. Mo… |
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