Anti-p-RAX/PACT [HL1921]

Rax (mouse protein) and PACT (human ortholog) are the only known activators of PKR (double-stranded RNA dependent kinase).

Contributors

Inventor Institute
Richard Bennett University of Florida Research Foundation
Cat. #: 158410
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell signaling and signal transduction
Application: ELISA ; WB ; IHC
Target: Phosphorylated interferon-inducible double strane RNA-dependent protein kinease/Protein activator of the interferon-induced protein kinase (RAX/PACT)
Reactivity: Human ; Rat ; Mouse
Host: Mouse
Class: Monoclonal
Alternate name: RAX/PACT; PRKRA
Product description: Rax (mouse protein) and PACT (human ortholog) are the only known activators of PKR (double-stranded RNA dependent kinase). Rax and PACT share 98% amino acid sequence homology and contain three conserved dsRNA binding motifs. Phosphorylation of Serine 18 of RAX is required for PKR activation, which is known to be involved in the host anti-viral response, and can act as a signaling mediator by cytokines, growth factors and even tumor supressors.
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: Synthetic peptide corresponding to amino acids 13-25, including phosphorylated Serine 18, of mouse PACT protein
Target background: Rax (mouse protein) and PACT (human ortholog) are the only known activators of PKR (double-stranded RNA dependent kinase). Rax and PACT share 98% amino acid sequence homology and contain three conserved dsRNA binding motifs. Phosphorylation of Serine 18 of RAX is required for PKR activation, which is known to be involved in the host anti-viral response, and can act as a signaling mediator by cytokines, growth factors and even tumor supressors.
Format: Liquid
Shipping conditions: Dry ice
References:

Bennett et al. 2004. J Biol Chem. 279(41):42687-93. PMID: 15299031.

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