Anti-Omomyc [21-1-3]

Monoclonal antibody specific for Omomyc, capable of suppressing Myc-induced oncogenesis.

Contributors

Inventor Institute
Laura Soucek Vall D'Hebron Institute Of Oncology (VHIO)
Cat. #: 153657
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Apoptosis and autophagy;Cancer;Cell biology;Genetics
Application: ELISA ; IHC ; IF ; WB
Target: Omomyc
Reactivity: Human
Clone: 17
Host: Mouse
Class: Monoclonal
Primary citation: Soucek et al. 2004. Cell Death Differ. 11(9):1038-45. PMID: 15143346.
Product description: Monoclonal antibody specific for Omomyc, capable of suppressing Myc-induced oncogenesis. Omomyc is a dominant-negative allele of the proto-oncogene Myc (c-Myc). Omomyc is a mutant bHLHZip domain that sequesters Myc in complexes that are unable to bind to the E box recognition element and activate transcription but remain competent for transcriptional repression. Expression of Omomyc can induce rapid tumour regression in mouse models with little toxicity for normal tissues, acting as a suppressor of Myc-induced oncogenesis.
Conjugation: Unconjugated
Isotype: IgG2a kappa
Target background: Monoclonal antibody specific for Omomyc, capable of suppressing Myc-induced oncogenesis. Omomyc is a dominant-negative allele of the proto-oncogene Myc (c-Myc). Omomyc is a mutant bHLHZip domain that sequesters Myc in complexes that are unable to bind to the E box recognition element and activate transcription but remain competent for transcriptional repression. Expression of Omomyc can induce rapid tumour regression in mouse models with little toxicity for normal tissues, acting as a suppressor of Myc-induced oncogenesis.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
Shipping conditions: Dry ice
References:

MassĂł-VallĂŠs D et al. 2022. Cancer Res Commun. 2(2):110-130. PMID: 36860495.

Fiorentino et al. 2016. Oncotarget. 7(21):31014-28. PMID: 27105536.

Soucek et al. 2013. Genes Dev. 27(5):504-13. PMID: 23475959.

Soucek et al. 2004. Cell Death Differ. 11(9):1038-45. PMID: 15143346.

​Bibbò et al. 2024. J Control Release. 374:171-180. PMID: 39128771.

Images

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IF staining of cells with anti-omomyc antibody

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