Monoclonal antibody directed against a marker of melanoma and metastasis.
| Inventor | Institute |
|---|---|
| Helen Turley | University of Oxford |
| Cat. #: | 151214 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Cell signaling and signal transduction;Immunology;Stem cell biology;Tissue-specific biology |
| Application: | FACS ; IHC ; IF |
| Target: | MUC18 (CD146) |
| Reactivity: | Human |
| Clone: | OJ79c MUC 18 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | ADMCKD, ADMCKD1, Breast carcinoma associated antigen DF3, Breast carcinoma-associated antigen DF3, CA 15-3, CA15 3, CA15 3 antigen, CA15.3, Cancer antigen 15-3, Carcinoma associated mucin, Carcinoma-associated mucin, CD 227, CD227 |
|---|---|
| Product description: | Monoclonal antibody directed against a marker of melanoma and metastasis. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 130 kDa |
| Immunogen: | Recombinant MUC18 (D1-D5) Fc chimeric protein |
| Immunogen Uniprot ID: | P43121 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | CD146 has been identified as a cell adhesion molecule and is useful in differential diagnosis of certain lesions including melanomas and various types of gestational trophoblastic lesions. CD146 is expressed at cell-cell junctions in all endothelial cells. In addition to its recognized role as a calcium-independent cell adhesion molecule, CD146 may also act as a signal transduction molecule in the recruitment of Fyn kinase, and in the subsequent tyrosine-phosphorylation of intracellular proteins involved in actin cytoskeleton assembly. CD146 expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogenous tumour spread. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease. It is associated with poor prognosis. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Smith et al. 2011. Immunology. 132(2):256-65. PMID: 21039468. Sato et al. 2010. Mod Pathol. 23(11):1458-66. PMID: 20657552. Mono- and tri-cationic porphyrin-monoclonal antibody conjugates: photodynamic activity and mechanism of action. Iohara et al. 2008. Stem Cells. 26(9):2408-18. PMID: 18583536. Crisan et al. 2008. Cell Stem Cell. 3(3):301-13. PMID: 18786417. A perivascular origin for mesenchymal stem cells in multiple human organs. A novel stem cell source for vasculogenesis in ischemia: subfraction of side population cells from dental pulp. Pruszak et al. 2007. Stem Cells. 25(9):2257-68. PMID: 17588935. Pruszak et al. 2007. Stem Cells. 25(9):2257-68. PMID: 17588935. Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations. Kuzu et al. 1993. Lab Invest. 69(3):322-8. PMID: 7690867. Expression of adhesion molecules on the endothelium of normal tissue vessels and vascular tumors. |
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