Anti- MHC class I [HC10]

Because MHC class I molecules present peptides derived from cytosolic proteins, the pathway of MHC class I presentation is often called cytosolic or endogenous pathway.

Contributors

Institute
Netherlands Cancer Institute
Cat. #: 154773
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell signaling and signal transduction;Immunology
Application: IHC ; IP ; WB
Target: MHC class I
Reactivity: Human ; Feline
Host: Mouse
Class: Monoclonal
Product description: MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHC class II) and are found on the cell surface of all nucleated cells in the bodies of jawed vertebrates. They also occur on platelets, but not on red blood cells. Their function is to display peptide fragments of proteins from within the cell to cytotoxic T cells; this will trigger an immediate response from the immune system against a particular non-self antigen displayed with the help of an MHC class I protein. Because MHC class I molecules present peptides derived from cytosolic proteins, the pathway of MHC class I presentation is often called cytosolic or endogenous pathway.
Conjugation: Unconjugated
Isotype: IgG2a
Immunogen: Immunized with HLA-B7 and -B40 heavy chains
Myeloma used: Sp2/0-Ag14
Target background: MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHC class II) and are found on the cell surface of all nucleated cells in the bodies of jawed vertebrates. They also occur on platelets, but not on red blood cells. Their function is to display peptide fragments of proteins from within the cell to cytotoxic T cells; this will trigger an immediate response from the immune system against a particular non-self antigen displayed with the help of an MHC class I protein. Because MHC class I molecules present peptides derived from cytosolic proteins, the pathway of MHC class I presentation is often called cytosolic or endogenous pathway.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Hundorfean et al. 2007. Am J Physiol Gastrointest Liver Physiol. 293(4):G798-808. PMID: 17673546.

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