#153644

Anti-Myelin Basic Protein (region Thr98) [98/P12]

Cat. #153644

Anti-Myelin Basic Protein (region Thr98) [98/P12]

Cat. #: 153644

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 10-12 weeks

Target: Myelin Basic Protein (region Thr98)

Class: Monoclonal

Application: ELISA ; WB

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Institute: BioServ UK Ltd

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-Myelin Basic Protein (region Thr98) [98/P12]
  • Alternate name: Myelin basic protein, MBP, 2 kDa microtubule-stabilizing protein, Myelin A1 protein
  • Cancer: Neurological cancer
  • Cancers detailed: Brain
  • Research fields: Cell biology;Immunology;Neurobiology
  • Clone: 98/P12
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Purpose: Marker
  • Conjugation: Unconjugated
  • Molecular weight: 13-21 kDa
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; WB
  • Description: The phosphorylation of myelin basic protein (MBP) has been shown to decrease the ability of MBP to aggregate lipid vesicles and consequently destabilising the compact structure of myelin, a destruction that has been observed in demyelinating diseases such as Multiple Sclerosis. (Yon, M et al. 1995) Clone 98/P12 is a useful detector of phosphorylated MBP by binding to Thr98 of human MBP in the phosphorylated state.
  • Immunogen: Synthetic peptide corresponding to human MBP when phosphorylated at threonine 98
  • Isotype: IgG2a
  • Myeloma used: Sp2/0-Ag14
  • Recommended controls: Brain tissue

Target Details

  • Target: Myelin Basic Protein (region Thr98)
  • Molecular weight: 13-21 kDa
  • Tissue cell line specificity: Mouse
  • Target background: The phosphorylation of myelin basic protein (MBP) has been shown to decrease the ability of MBP to aggregate lipid vesicles and consequently destabilising the compact structure of myelin, a destruction that has been observed in demyelinating diseases such as Multiple Sclerosis. (Yon, M et al. 1995) Clone 98/P12 is a useful detector of phosphorylated MBP by binding to Thr98 of human MBP in the phosphorylated state.

Applications

  • Application: ELISA ; WB

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Shipping conditions: Shipping at 4° C

References

  • DeBruin et al. 2006. Biochem Cell Biol. 84(6):993-1005. PMID: 17215885.
  • Partitioning of myelin basic protein into membrane microdomains in a spontaneously demyelinating mouse model for multiple sclerosis.
  • DeBruin et al. 2005. J Neurosci Res. 80(2):211-25. PMID: 15772981.
  • Developmental partitioning of myelin basic protein into membrane microdomains.
  • Atkins et al. 1999. J Neurochem. 73(3):1090-7. PMID: 10461899.
  • Regulation of myelin basic protein phosphorylation by mitogen-activated p...