Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 8 and 18 are two of the first keratins expressed in the embryo, […]
| Inventor | Institute |
|---|---|
| Birgit Lane | University of Dundee |
| Cat. #: | 151317 |
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| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction |
| Application: | ELISA ; FACS ; IHC ; IF ; IP ; WB |
| Target: | Keratin 18 |
| Reactivity: | Human ; Mouse ; Pig |
| Clone: | LDK18 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 8 and 18 are two of the first keratins expressed in the embryo, and persist into adult tissues as the keratin pair representing minimal epithelial keratin expression. Keratins 8 and 18 are major components of all simple epithelia (but not of stratified squamous epithelia) and adenocarcinomas. |
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| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | Synthetic peptide of human keratin 18 (CSETNDTKVLRH-COOH) |
| Target background: | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 8 and 18 are two of the first keratins expressed in the embryo, and persist into adult tissues as the keratin pair representing minimal epithelial keratin expression. Keratins 8 and 18 are major components of all simple epithelia (but not of stratified squamous epithelia) and adenocarcinomas. |
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| Format: | Liquid |
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| Concentration: | 1mg/ml |
| Storage buffer: | DMEM + 5% FCS |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Hosoya A et al. Anat Rec (Hoboken). 2010 Nov 293(11):1864-72. PMID: 20818615 D'Alessandro M et al. J Invest Dermatol. 2011 Jul 131(7):1412-9. PMID: 21326298 |
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