Integrins are heterodimeric cell surface receptors composed of a and b subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a3 is found on most […]
| Inventor | Institute |
|---|---|
| Joyce Taylor-Papadimitriou | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151096 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology |
| Application: | IHC ; IF |
| Target: | Integrin a3 (CD49c) |
| Reactivity: | Human |
| Clone: | F35 177-1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Gaggioli et al. 2007. Nat Cell Biol. 9(12):1392-400. PMID: 18037882. |
| Product description: | Integrins are heterodimeric cell surface receptors composed of a and b subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a3 is found on most cell types. Integrin a3 associates with b1 integrin to form integrin a3b1, which is one of the most abundant keratinocyte integrins and binds laminin 5. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 14 kDa |
| Immunogen: | MTSV1-7 HYE – human breast epithelial cells. |
| Myeloma used: | P3X63Ag8.653 |
| Target background: | Integrins are heterodimeric cell surface receptors composed of a and b subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a3 is found on most cell types. Integrin a3 associates with b1 integrin to form integrin a3b1, which is one of the most abundant keratinocyte integrins and binds laminin 5. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Lustosa et al. 2014. ScientificWorldJournal. 2014:102541. PMID: 24737953. McInroy et al. 2011. Exp Cell Res. 317(17):2468-78. PMID: 21821021. Gaggioli et al. 2007. Nat Cell Biol. 9(12):1392-400. PMID: 18037882. |
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