#162208

Anti-HSPB1p78 [2.1]

Cat. #162208

Anti-HSPB1p78 [2.1]

Cat. #: 162208

Sub-type: Primary antibody

Unit size: 100 ug

Target: human heat shock protein 27 phosphorylated at site 78, HSP27p78

Class: Monoclonal

Application: WB ; IP ; IHC

Reactivity: Human

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Roy Quinlan

Institute: University of Durham

Primary Citation: P A Eyers, et al. 1999. FEBS Lett. 21;451(2):191-6. PMID: 10371163

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-HSPB1p78 [2.1]
  • Alternate name: HSPB1p78 ; HSP26p78
  • Research fields: Array
  • Clone: 2.1
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Molecular weight: 27kDa, 205 residues
  • Reactivity: Human
  • Application: WB ; IP ; IHC
  • Description: A monoclonal antibody for HSPB1p78 also known as HSP27p78. This antibody targets HSPB1 (HSP27) a small heat shock protein which is involved in TP53 turnover, steroid receptor maturation, cytoskeletal dynamics, regulation of proteostasis and apoptosis. This antibody recognises HSPB1 when phosphorylated at serine 78. Phosphorylation of HSP27 can cause conformational changes in the tertiary structure resulting in decreased oligomeric size.
  • Immunogen: peptide crosslinked to KLH
  • Isotype: IgG

Target Details

  • Target: human heat shock protein 27 phosphorylated at site 78, HSP27p78
  • Target alternate names: HSPB1p78 ; HSP26p78
  • Molecular weight: 27kDa, 205 residues
  • Target background: Hsp27 is an ATP-independent molecular chaperone with well-described tumorigenic and metastatic roles, characterized by its dynamic phosphorylation leading to heterogeneous oligomerization under different conditions such as stress

Applications

  • Application: WB ; IP ; IHC

Handling

  • Format: Liquid
  • Concentration: 1mg/ml
  • Unit size: 100 ug
  • Storage buffer: tissue culture media with cryoprotectant
  • Storage conditions: liquid nitrogen
  • Shipping conditions: Dry ice

References

  • Philip R Quinlan, et al. 2021. Cell Stress Chaperones. 27(2):177-188. PMID: 35235182.
  • Alamgir M N Kabir, et al. 2005. J Mol Cell Cardiol. 39(4):709-17. PMID: 16140323
  • P A Eyers, et al. 1999. FEBS Lett. 21
  • 451(2):191-6. PMID: 10371163