Anti-HLA-DR [TAL 16.1]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-HLA-DR [TAL 16.1]
• Research fields: Immunology
• Clone: TAL 16.1
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Molecular weight: 29 kDa
• Reactivity: Human
• Host: Mouse
• Application: ELISA ; FACS ; IHC ; WB
• Description: Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). TAL 16.1 is useful for distinguishing DR1 homozygotes from DR1, DR103 heterozygotes.
• Immunogen: Mouse L cell transfected with a Human HLA Class II (HLADRB5*0101) gene
• Isotype: IgG2a
• Myeloma used: NS0

Target Details

• Target: Human leukocyte antigens DR16, 103, 11, 12, 13, 8, 7, 4 (Dw10 only), DR51
• Molecular weight: 29 kDa
• Target background: Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). TAL 16.1 is useful for distinguishing DR1 homozygotes from DR1, DR103 heterozygotes.

Applications

• Application: ELISA ; FACS ; IHC ; WB

Handling

• Format: Liquid
• Concentration: 1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

• Sadler et al. 1993. Tissue Antigens. 41(1):42-6. PMID: 7681224.
• The monoclonal antibody TAL16.1 recognizes the aspartic acid residue at position 70 in DRB gene products.
• Altmann et al. 1990. Immunogenetics. 32(1):51-5. PMID: 1695613.
• Fine mapping of HLA class II monoclonal antibody specificities using transfected L cells.