3G12 is a marker for mucus-secreting cells in the posterior gut of zebrafish.
| Inventor | Institute |
|---|---|
| Cecile Wright-Crosnier ; Julian Lewis ; Linda Ariza-McNaughton ; Neil Vargesson | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151516 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Application: | IHC ; IF ; WB |
| Target: | Goblet cells in the posterior part of the zebrafish intestine |
| Reactivity: | Zebrafish |
| Clone: | FIS 3G12/3 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | 3G12 is a marker for mucus-secreting cells in the posterior gut of zebrafish. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 175 kDa, 120 kDa, 70 kDa |
| Immunogen: | Lysate of fish gut intestine |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | The transparency of the juvenile zebrafish and its genetic advantages make it an attractive model for the study of intestinal differentiation and renewal. Antibody 3G12 marks goblet cells specifically. It labels both the mucus compartment and other parts of the cytoplasm. On Western blots, 3G12 stains diffuse bands, consistent with variably glycosylated antigen(s). 3G12 labelled cells are concentrated in the posterior gut. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Crosnier et al. 2005. Development. 132(5):1093-104. PMID: 15689380. Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine. |
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