Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are nearly absent in extracellular matrix of normal adult tissues but upregulated in malignant tissues. Both FN-EDB and TNC-C are developed as targets of antibody-based therapies.This series of antibodies has been validated in vitro against glioblastoma (GBM) and prostate carcinoma xenografts, and to non-malignant angiogenic neovessels induced […]
| Inventor | Institute |
|---|---|
| Tambet Teesalu | University of Tartu |
| Cat. #: | 160456 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology |
| Application: | ELISA ; IHC |
| Target: | Extra domain B of fibronectin, EDB-FN |
| Reactivity: | Human |
| Class: | Monoclonal |
| Product description: | Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are nearly absent in extracellular matrix of normal adult tissues but upregulated in malignant tissues. Both FN-EDB and TNC-C are developed as targets of antibody-based therapies.This series of antibodies has been validated in vitro against glioblastoma (GBM) and prostate carcinoma xenografts, and to non-malignant angiogenic neovessels induced by VEGF-overexpression. Please see our related anti-FN-EDB antibodies from University of Tartu. |
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| Conjugation: | Unconjugated |
| Target background: | Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are nearly absent in extracellular matrix of normal adult tissues but upregulated in malignant tissues. Both FN-EDB and TNC-C are developed as targets of antibody-based therapies. This series of antibodies has been validated in vitro against glioblastoma (GBM) and prostate carcinoma xenografts, and to non-malignant angiogenic neovessels induced by VEGF-overexpression. Please see our related anti-FN-EDB antibodies from Universit… |
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| Format: | Liquid |
|---|---|
| Shipping conditions: | Dry ice |
| References: |
Lingasamy et al. 2019. Biomaterials. 219:119373. PMID: 31374479. |
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