PR 4D1 may be useful for histological diagnosis of colon disorders. Wide reactivity with GI tract. Reacts with a high MW glycoprotein in human colonic mucus, epithelial cells and cell membranes.
| Inventor | Institute |
|---|---|
| Walter Bodmer | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151153 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Cell signaling and signal transduction |
| Application: | IHC |
| Target: | Epithelia (colonic) |
| Reactivity: | Human |
| Clone: | PR 4D1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | PR 4D1 may be useful for histological diagnosis of colon disorders. Wide reactivity with GI tract. Reacts with a high MW glycoprotein in human colonic mucus, epithelial cells and cell membranes. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 140 kDa |
| Immunogen: | Mucosal scrapings and membrane preparations from normal colorectal epithelium and possibly booster inoculations with the colon carcinoma cell line HT29. |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | PR 2D3 reacts with a cell membrane component of cells in the pericrypt sheath; with smooth muscle cells and myofibroblasts. This antibody is considered to be the gold standard for the identification of myofibroblasts. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Richman et al. 1987. Int J Cancer. 39(3):317-28. PMID: 2434440. Monoclonal antibodies to human colorectal epithelium: markers for differentiation and tumour characterization. |
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