Anti-CUL-4A

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-CUL-4A
• Alternate name: CUL-4A
• Research fields: Biochemistry;Cancer;Cell biology;Genetics
• Tool sub type: Primary antibody
• Class: Polyclonal
• Conjugation: Unconjugated
• Reactivity: Human ; Mouse
• Host: Rabbit
• Application: WB ; IP ; ChIP ; ELISA ; IHC
• Description: CUL-4A regulates numerous key processes such as DNA repair, chromatin remodeling, spermatogenesis, haematopoiesis and the mitotic cell cycle. Moreover, CUL-4A is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a result, CUL-4A has been implicated in several cancers and the pathogenesis of certain viruses including HIV.
• Immunogen: Synthetic peptide (ERDKDNPNQYHYVA) (746-759, C-terminus peptide), corresponding to human CUL-4A was conjugated to maleimide-activated keyhole limpet hemocyanin

Target Details

• Target: Cullin 4A
• Target background: CUL-4A regulates numerous key processes such as DNA repair, chromatin remodeling, spermatogenesis, haematopoiesis and the mitotic cell cycle. Moreover, CUL-4A is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a result, CUL-4A has been implicated in several cancers and the pathogenesis of certain viruses including HIV.

Applications

• Application: WB ; IP ; ChIP ; ELISA ; IHC

Handling

• Format: Liquid
• Unit size: 100 ug
• Shipping conditions: Shipping at 4° C

References

• Sharma et al. 2014. Open Biol. 4:130217. PMID: 24522884.
• Shiyanov et al. 1999. J Biol Chem. 274(50):35309-12. PMID: 10585395.