CHD4/Mi-2b is a component of the nucleosome remodeling and deacetylase (NuRD) complex which is a multi-subunit protein complex containing both histone deacetylase and nucleosome-dependent ATPase subunits.
| Institute |
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| Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151462 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics;Immunology |
| Application: | ChIP ; ELISA ; FACS ; IF ; IHC ; IP ; WB |
| Target: | Chromodomain-helicase-DNA-binding protein 4 (CHD4/Mi2b) |
| Reactivity: | Mouse ; Human |
| Clone: | CHD4 3F2/4 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | CHD4/Mi-2b is a component of the nucleosome remodeling and deacetylase (NuRD) complex which is a multi-subunit protein complex containing both histone deacetylase and nucleosome-dependent ATPase subunits. Current models predict that this complex functions primarily in transcriptional repression. Accumulating evidence indicates that NuRD may regulate the transcription of specific genes by interacting with specific transcriptional factors. In addition, the NuRD complex may also participate in genome-wide transcriptional regulation through an association with histone tails. |
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| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Synthetic peptide (N- and C- terminal peptides were used for immunisation. 1. ASGLGSPSPCSAGSEEEDM & 2. CSRLANRAPEPPPQQVAQQQ. Which peptide the antibody recognises has not been tested) |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | CHD4/Mi-2b is a component of the nucleosome remodeling and deacetylase (NuRD) complex which is a multi-subunit protein complex containing both histone deacetylase and nucleosome-dependent ATPase subunits. Current models predict that this complex functions primarily in transcriptional repression. Accumulating evidence indicates that NuRD may regulate the transcription of specific genes by interacting with specific transcriptional factors. In addition, the NuRD complex may also participate in genome-wide transcriptional regulation through an association with histone tails. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -80° C |
| Shipping conditions: | Dry ice |
| References: |
Sparmann et al. 2013. EMBO J. 32(11):1598-612. PMID: 23624931. The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation. Curtis et al. 2012. Mol Cell Biol. 32(7):1312-20. PMID: 22290435. The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling. Ramrez et al. 2009. Epigenetics. 4(8):532-6. PMID: 19923891. The Mi-2/NuRD complex: a critical epigenetic regulator of hematopoietic development, differentiation and cancer. |
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