Anti-CD8 [SPVT8]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-CD8 [SPVT8]
• Alternate name: Leu2 T-Lymphocyte Antigen; OKT8 T-Cell Antigen
• Research fields: Cell biology;Immunology
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Molecular weight: 32 kDa
• Strain: Balb/c
• Reactivity: Human
• Host: Mouse
• Application: FACS ; IP
• Description: CD8 is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein. The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells, cortical thymocytes, and dendritic cells. The CD8 molecule is a marker for cytotoxic T cell population. It is expressed in T cell lymphoblastic lymphoma and hypo-pigmented mycosis fungoides
• Immunogen: Human cytotoxic T-lymphocytes
• Isotype: IgG1
• Myeloma used: Sp2/0-Ag14

Target Details

• Target: CD8
• Molecular weight: 32 kDa
• Target background: CD8 is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein. The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells, cortical thymocytes, and dendritic cells. The CD8 molecule is a marker for cytotoxic T cell population. It is expressed in T cell lymphoblastic lymphoma and hypo-pigmented mycosis fungoides

Applications

• Application: FACS ; IP

Handling

• Format: Liquid
• Concentration: 0.9-1.1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

• de Vries et al. 1984. J Immunol. 132(1):510-9. PMID: 6197458.
• Spits et al. 1983. Hybridoma. 2(4):423-37. PMID: 6332061.