Anti-CD49b [16B4]

CD49b is an integrin alpha subunit which makes up half of the a2?1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain

Contributors

Inventor Institute
Martin Humphries University of Manchester
Cat. #: 152483
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell biology;Cell signaling and signal transduction;Immunology
Application: ELISA ; FACS ; IHC ; IF ; IP
Target: CD49f (Integrin a2+b1)
Reactivity: Human
Clone: 16B4
Host: Mouse
Class: Monoclonal
Alternate name: Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor; Alpha-2 Subunit; Human Platelet Alloantigen System; Platelet Glycoprotein GPIa; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR
Product description: CD49b is an integrin alpha subunit which makes up half of the Î?2Î?1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: Purified human beta 1 preparation from HT1080 fibrosarcoma cell extract.
Myeloma used: P3X63Ag8.653
Target background: CD49b is an integrin alpha subunit which makes up half of the a2?1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Suarez et al. 2015. Arch Dermatol Res. 307(2):115-33. PMID: 25322916.

Menhofer et al. 2014. Cardiovasc Res. 104(2):303-14. PMID: 25239826.

Identification of biomarkers involved in differential profiling of hypertrophic and keloid scars versus normal skin.

In vitro and in vivo characterization of the actin polymerizing compound chondramide as an angiogenic inhibitor.

Tuckwell et al. 2000. Biochem J. 350 Pt 2:485-93. PMID: 10947963.

Monoclonal antibodies identify residues 199-216 of the integrin alpha2 vWFA domain as a Fnly important region within alpha2beta1.

Sincock et al. 1999. J Cell Sci. 112 ( Pt 6):833-44. PMID: 10036233.

PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function.

Fitter et al. 1999. Biochem J. 338 ( Pt 1):61-70. PMID: 9931299.

Transmembrane 4 superfamily protein CD151 (PETA-3) associates with beta 1 and alpha IIb beta 3 integrins in haemopoietic cell lines and modulates cell-cell adhesion.

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