R4/23 recognises the long form of CR2 and can be used to identify dendritic reticulum cells (or their remnants) in lymphoid tissues.
| Inventor | Institute |
|---|---|
| Jacqueline Cordell | University of Oxford |
| Cat. #: | 151355 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Immunology |
| Application: | IHC ; WB |
| Target: | Complement component (3d/Epstein Barr virus) receptor 2; long form (CR2, CD21L) |
| Reactivity: | Human |
| Clone: | R4/23 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Complement Component (3d/Epstein Barr Virus) Receptor 2; Epstein-Barr Virus Receptor 2; Complement C3d Receptor 3; EBV Receptor 3; C3DR 3; CD21 Antigen; CVID7; SLEB9; CD21; Cr2 |
|---|---|
| Product description: | R4/23 recognises the long form of CR2 and can be used to identify dendritic reticulum cells (or their remnants) in lymphoid tissues. |
| Conjugation: | Unconjugated |
| Isotype: | IgM |
| Immunogen: | Cell lysate from a chronic lymphocytic leukemia patient. |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. Follicular dendritic cells (contained in B cell follicles) selectively express the Long isoform of CR2 (CD21L) that contains an additional exon (10a) compared to CR2 (CD21). |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Nakamura et al. 1999. Am J Surg Pathol. 23(4):363-76. PMID: 10199466. Hodgkin's disease expressing follicular dendritic cell marker CD21 without any other B-cell marker: a clinicopathologic study of nine cases. Heinen et al. 1984. Eur J Immunol. 14(3):267-73. PMID: 6368249. Isolation of follicular dendritic cells from human tonsils and adenoids. II. Immunocytochemical characterization. Naiem et al. 1983. J Clin Pathol. 36(2):167-75. PMID: 6338047. Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue. Stein et al. 1982. Int J Cancer. 30(4):445-59. PMID: 6754630. Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population. |
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