von Willebrand factor (vWF) is a multimeric glycoprotein that functions in hemostasis as the initiator of platelet adhesion at the site of vascular injury and as the carrier of the anti-hemophilic factor, factor VIII (FVIII). Hereditary or acquired defects of VWF lead to von Willebrand disease (vWD), a bleeding diathesis of the skin and mucous […]
| Institute |
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| Versiti Blood Research Institute |
| Cat. #: | 155090 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Immunology |
| Application: | ELISA ; IF ; IP ; WB |
| Target: | von Willebrand Factor |
| Reactivity: | Human |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | vWf |
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| Product description: | von Willebrand factor (vWF) is a multimeric glycoprotein that functions in hemostasis as the initiator of platelet adhesion at the site of vascular injury and as the carrier of the anti-hemophilic factor, factor VIII (FVIII). Hereditary or acquired defects of VWF lead to von Willebrand disease (vWD), a bleeding diathesis of the skin and mucous membranes, causing nosebleeds, menorrhagia, and gastrointestinal bleeding. |
| Conjugation: | Unconjugated |
| Molecular weight: | 250 kDa |
| Immunogen: | vWF (COOH terminus of mature vWF) |
| Myeloma used: | P3X63Ag8.653 |
| Target background: | von Willebrand factor (vWF) is a multimeric glycoprotein that functions in hemostasis as the initiator of platelet adhesion at the site of vascular injury and as the carrier of the anti-hemophilic factor, factor VIII (FVIII). Hereditary or acquired defects of VWF lead to von Willebrand disease (vWD), a bleeding diathesis of the skin and mucous membranes, causing nosebleeds, menorrhagia, and gastrointestinal bleeding. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Flood et al. 2018. Res Pract Thromb Haemost. 2(2):390-398. PMID: 30046743. Haberichter et al. 2008. Blood. 111(10):4979-85. PMID: 18344424. Rosenberg et al. 2002. Blood. 100(5):1699-706. PMID: 12176890. Hillery et al. 1998. Blood. 91(5):1572-81. PMID: 9473222. Rosenberg et al. 1998. J Clin Invest. 101(3):613-24. PMID: 9449695. Scott et al. 1991. Am J Clin Pathol. 96(6):723-8. PMID: 1746488. Kroner et al. 1991. J Biol Chem. 266(29):19146-9. PMID: 1918030. Montgomery et al. 1986. … |
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