Anti-ASPP1 [ASPP1]

iASPP1 inhibits the proaptotic functions of ASPP1 and p53.

Contributors

Inventor Institute
David Elliott Newcastle University
Cat. #: 151751
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Stem cell biology
Application: IF ; IP ; WB
Target: ASPP1
Reactivity: Human
Clone: ASPP1
Host: Sheep
Class: Polyclonal
Product description: iASPP1 inhibits the proaptotic functions of ASPP1 and p53.
Conjugation: Unconjugated
Immunogen: Amino acids from human ASPP1 357-532
Target background: Stimulating protein of p53 (ASPP) contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. There are three known types of ASPP: ASPP1, ASPP2 and iASPP1.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Thornton et al. 2006. Oncogene. 25(22):3104-12. PMID: 16474851.

The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo.

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