Cat. #151751
Anti-ASPP1 [ASPP1]
Cat. #: 151751
Sub-type: Primary antibody
Unit size: 100 ug
Target: ASPP1
Class: Polyclonal
Application: IF ; IP ; WB
Reactivity: Human
Host: Sheep
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: David Elliott
Institute: Newcastle University
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-ASPP1 [ASPP1]
- Research fields: Cancer;Stem cell biology
- Clone: ASPP1
- Tool sub type: Primary antibody
- Class: Polyclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Sheep
- Application: IF ; IP ; WB
- Description: iASPP1 inhibits the proaptotic functions of ASPP1 and p53.
- Immunogen: Amino acids from human ASPP1 357-532
Target Details
- Target: ASPP1
- Target background: Stimulating protein of p53 (ASPP) contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. There are three known types of ASPP: ASPP1, ASPP2 and iASPP1.
Applications
- Application: IF ; IP ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Thornton et al. 2006. Oncogene. 25(22):3104-12. PMID: 16474851.
- The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo.
