ADAM9 encodes disintegrin and metalloprotease (ADAM) domain 9, which is a member of the ADAM protein family. Members of this family are membrane- anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell- cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis.
| Inventor | Institute |
|---|---|
| Carl Blobel | Hospital for Special Surgery |
| Cat. #: | 152538 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell signaling and signal transduction |
| Application: | WB |
| Target: | ADAM9 |
| Reactivity: | Mouse |
| Clone: | 9MO |
| Host: | Rabbit |
| Class: | Polyclonal |
| Product description: | ADAM9 encodes disintegrin and metalloprotease (ADAM) domain 9, which is a member of the ADAM protein family. Members of this family are membrane- anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell- cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The member encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. |
|---|---|
| Conjugation: | Unconjugated |
| Molecular weight: | ~84 kDa (mature form), 115 kDa (pro-form) |
| Immunogen: | GST-cyto corresponding to the cytoplasmic domain of murine ADAM9 |
| Target background: | ADAM9 encodes disintegrin and metalloprotease (ADAM) domain 9, which is a member of the ADAM protein family. Members of this family are membrane- anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell- cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The member encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | Whole serum |
| Storage conditions: | -20° C |
| Shipping conditions: | Dry ice |
| References: |
Guaiquil et al. 2009. Mol Cell Biol. 29(10):2694-703. PMID: 19273593. Peduto et al. 2005. Cancer Res. 65(20):9312-9. PMID: 16230393. Roghani et al. 1999. J Biol Chem. 274(6):3531-40. PMID: 9920899. ADAM9 is involved in pathological retinal neovascularization. Critical function for ADAM9 in mouse prostate cancer. Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity. Weskamp et al. 1996. J Cell Biol. 132(4):717-26. PMID: 8647900. MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. |
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