UOL-Hep-CYB5 cell line

This cell line consists of HepG2 cybrid cell lines negative for cellular mitochondrial DNA, fused with different platelet partners (platelets contain only mitochondrial DNA and no nuclear DNA). Each cybrid cell line has a combination of SNPs in mitochondrial DNA, relevant to a variety of diseases. Cybrid cell line panel has potential use for drug testing

Contributors

Inventor Institute
Amy Chadwick University of Liverpool, Molecular and Clinical Pharmacology
Cat. #: 161128
Research Fields: Drug development
Organism: Human
Tissue: Liver
Growth properties: Adherent
Product description: This cell line consists of HepG2 cybrid cell lines negative for cellular mitochondrial DNA, fused with different platelet partners (platelets contain only mitochondrial DNA and no nuclear DNA). Each cybrid cell line has a combination of SNPs in mitochondrial DNA, relevant to a variety of diseases. Cybrid cell line panel has potential use for drug testing
Additional notes: Parental cell line was purchased from ECACC
Parental cell line: HepG2
Model description: Cybrid Cell Line
Disease: Mitochondrial Subhaplogroup : H1bb
Growth medium: DMEM high-glucose medium (glucose; 25?mM) supplemented with FBS (10 % v/v), L-glutamine (4?mM), sodium pyruvate (1?mM), and HEPES (1?mM)
Subculture routine: Cells are subcultured weekly (1:12) via trypsinisation.
Temperature: 37° C
Atmosphere: 5% CO2

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