Cat. #156416
Mutant DISC1 cell line
Cat. #: 156416
Unit size: 1x10^6 cells / vial
Availability: 10-12 weeks
Disease: Schizophrenia
£575.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Mikhail Plentnikov
Institute: Johns Hopkins University
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Mutant DISC1 cell line
- Research fields: Drug development;Neurobiology
- Parental cell: PC12
- Disease: Schizophrenia
- Description: To evaluate the effects of a predicted protein, mutant disrupted-in-schizophrenia 1 (DISC1), stable PC12 cell clones with inducible expression of mutant or full-length human DISC1 (hDISC1) have been generated. PC12 is a neuronal cell line derived from a pheochromocytoma of the rat brain. This technology includes an inducible Tet-off PC12 cell model with stable expression of full-length and truncated hDISC1, allowing for a regulated expression of hDISC1 in homogenous populations of cells. Inducible expression of DISC1 in PC12 cells is a valuable in vitro model for further studying the molecular mechanisms likely due to loss of function of DISC1 relevant to the pathogenesis of major mental illnesses.
Target Details
- Target: disrupted-in-schizophrenia 1 (DISC1)
Handling
- Format: Frozen
- Unit size: 1x10^6 cells / vial
- Shipping conditions: Dry ice
