R-3327 AT.2 cell line

AT-2 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 month-old inbred Copenhagen male rat in 1961. R3327 has been maintained by continuous serial passage in rats for many years. AT-2 was identified in 1981 and was the second of such anaplastic tumors to arise.

Contributors

Inventor Institute
John Isaacs Johns Hopkins University
Cat. #: 156411
Unit size: 1×10^6 cells / vial
Cancer types: Genitourinary cancer
Research Fields: Cancer;Drug development
Model: Cancer Model
Cancer Types In Detail: Prostate
Product description: AT-2 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 month-old inbred Copenhagen male rat in 1961. R3327 has been maintained by continuous serial passage in rats for many years. AT-2 was identified in 1981 and was the second of such anaplastic tumors to arise. Following subcutaneous transplantation in syngeneic male rats, AT-2 forms solid sheets of malignant cells with no indication of glandular function. These tumors are androgen-independent and grow continuously with a doubling time of approximately 2.5 days. AT-2 exhibits a low to moderate metastatic ability (<20% of rats inoculated sub-cutaneously develop distant metastases). The AT-2 subline can be used to study the effects of various types of cancer therapies on prostate cells.
Cellosaurus ID: CVCL_L303
disease: Cancer
Format: Frozen
Shipping conditions: Dry ice
References:

Musialik et al. 2013. Oncol Rep. 29(5):1789-96. PMID: 23467722.

Isaacs et al. 1986. Prostate. 9(3):261-81. PMID: 3774632.

Related Tools for Cell lines

Cat. # Tool Name
151425 TR146 Cell Line Key Info View Tool
151446 FLYRD18 Cell Line Key Info View Tool
151447 CMT 64 Cell Line Key Info View Tool
151665 MEF PKCe KO Cell Line Key Info View Tool
151448 CMT 167 Cell Line Key Info View Tool

Related News

UM-UC-10 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC), UK.
Cell Lines

Popular cell lines now available only from CancerTools.org

Read More
Cell Lines

New cell lines: murine melanocyte and melanoblast cell lines from Dr. Elena Sviderskaya

Read More
Image Reference: 2x PTEN -/- mouse prostate cancer cell lines (MuCap system). Histology staining of syngraft tumours (Van Duijn et al., 2018).
Cell Lines

38 new prostate cancer cell lines

Read More

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.