R-3327 AT.2 cell line
AT-2 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 month-old inbred Copenhagen male rat in 1961. R3327 has been maintained by continuous serial passage in rats for many years. AT-2 was identified in 1981 and was the second of such anaplastic tumors to arise.
Contributors
| Inventor | Institute |
|---|---|
| John Isaacs | Johns Hopkins University |
| SKU: | 156411 |
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| Product description: | AT-2 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 month-old inbred Copenhagen male rat in 1961. R3327 has been maintained by continuous serial passage in rats for many years. AT-2 was identified in 1981 and was the second of such anaplastic tumors to arise. Following subcutaneous transplantation in syngeneic male rats, AT-2 forms solid sheets of malignant cells with no indication of glandular function. These tumors are androgen-independent and grow continuously with a doubling time of approximately 2.5 days. AT-2 exhibits a low to moderate metastatic ability (<20% of rats inoculated sub-cutaneously develop distant metastases). The AT-2 subline can be used to study the effects of various types of cancer therapies on prostate cells. |
| Cellosaurus ID: | CVCL_L303 |
| Disease: | Cancer |
| Cat. #: | 156411 |
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| Unit size: | 1×10^6 cells / vial |
| Cancer types: | Prostate cancer |
| Research Fields: | Cancer; Drug development |
| Model: | Cancer Model |
| Cancer Types In Detail: | Prostate |
| Format: | Frozen |
|---|---|
| Shipping conditions: | Dry ice |
| References: |
Musialik et al. 2013. Oncol Rep. 29(5):1789-96. PMID: 23467722. Isaacs et al. 1986. Prostate. 9(3):261-81. PMID: 3774632. |
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